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The Role and Molecular Mechanisms of Epithelial-Mesenchymal Transition (EMT) in the Progression of Esophageal Squamous Cell Carcinoma

Abstract

This paper systematically explored the critical role and associated molecular mechanisms of epithelial-mesenchymal transition (EMT) in the progression of esophageal squamous cell carcinoma (ESCC). Through a comprehensive literature review, the major molecular markers of EMT in ESCC and its mechanisms in promoting tumor invasion and metastasis were analyzed. These mechanisms include the reduction of cell adhesion, enhancement of mesenchymal traits and motility, and facilitation of extracellular matrix degradation. Studies have shown that during EMT, the expression of epithelial markers such as E-cadherin is downregulated, while mesenchymal markers such as N-cadherin and vimentin are upregulated. These changes significantly enhance the invasive and metastatic potential of tumor cells. As a key driver of ESCC progression, EMT not only sheds light on the biological characteristics of this disease but also provides a theoretical basis for developing novel therapeutic strategies and improving patient prognosis

Keywords

EMTesophageal squamous cell carcinomainvasion metastasis

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